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Clonidine overdose. Hypertensive crisis and myocardial infarction following massive .... Medlineplus drug information: clonidine (systemic).

Emedicine - toxicity, clonidine : article by david riley, md, rdms.

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Clonidine overdose in childhood: implications of increased ...

Clonidine overdose. T becoming one of the agents most responsible for coma in young children. As little as 0.1 mg can cause toxic symptoms.1 However, a definite range of toxicity has not yet been determined. Common symptoms include profound hypotension, respiratory depression, bradycardia and CNS depression.2 Respirations can be irregular and proceed to intermittent apneic episodes. Varying levels of unconsciousness may be observed. Onset of symptoms generally occurs within 30 minutes to two hours following exposure. Symptoms usually resolve completely within 24-48 hours. Peak hypotensive effects are usually seen within 2-4 hours. Since patients may become lethargic or comatose quickly, Syrup of Ipecac-induced emesis carries with it obvious risks. Gastric lavage may be of use if exposure has occured within the last 1-2 hours. Activated charcoal with a cathartic should be administered. Monitor vital signs and ECG frequently and regularly. Naloxone (Narcan®) may be useful in reversing hypotension, bradycardia and coma because of the similarity of clonidine to opiate overdose symptoms. Treatment with naloxone is controversial and has been reported to cause hypertension.3-5 However, transient hypertension can be seen from clonidine alone. Hypotension may respond to IV fluids and in the Trendelenburg position. If hypotension is unresponsive, dopamine may be used. Hypotension and bradycardia, if severe, may respond to atropine. Hypertensive episodes are usually transient and should be treated cautiously if pharmaceutical intervention is warranted. Nitroprusside (Nipride®) is the drug of choi clonidine overdose		  

Ingentaconnect clonidine overdose: cardiovascular and cns ...

Profile Links HomoloGene Links Nucleotide Links Nucleotide (RefSeq) Links OMIA Links OMIM (calculated) Links OMIM (cited) Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links Protein (RefSeq) Links SNP Links Structure Links Taxonomy via GenBank UniGene Links UniSTS Links Show 5 10 20 50 100 200 500 Sort by Pub Date First Author Last Author Journal Send to Text File Printer Clipboard E-mail Order All: 1 Review: 1 1: Ann Emerg Med. 1981 Feb;10(2):107-12. Related Articles, Links Clonidine overdose: report of six cases and review of the literature.Anderson RJ, Hart GR, Crumpler CP, Lerman MJ.Clonidine poisoning usually causes depressed sensorium, hypotension, and bradycardia. Some patients manifest respiratory depression and miosis simulating narcotic overdose. Supportive care with judicious administration of intravenous fluids, occasionally supplemented by a dopamine infusion, usually reestablished adequate blood pressure. Tolazoline, an alpha-blocker, may reverse clonidine's effects should other efforts fail. Atropine should be used if bradycardia is hemodynamically significant. With massive overdose, clonidine's partial alpha-agonist properties may predominate, resulting in marked hypertension requiring cautious therapy. The experience at Parkland Memorial Hospital with clonidine overdose in six patients demonstrates the myriad of clinical presentations possible.Publication Types: Case Reports Review PMID: 7013572 PubMed - indexed for MEDLINE Display Summary Brief Abstract Abstr clonidine overdose


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Ose is a potentially serious condition, often requiring intensive care management. Our experience suggests that it is a growing problem, related in part to its increased use in the treatment of ADHD. Preventive strategies, including raising the level of awareness of risks, changes to packaging and appropriate selection of patients for treatment, need consideration if further overdoses are to be prevented.PMID: 9928640 PubMed - indexed for MEDLINE Display Summary Brief Abstract AbstractPlus Citation MEDLINE XML UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Gene (GeneRIF) Links Genome Links Project Links GENSAT Links GEO Profile Links HomoloGene Links Nucleotide Links Nucleotide (RefSeq) Links OMIA Links OMIM (calculated) Links OMIM (cited) Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links P

clonidine overdose 34 clonidine overdose, No. 5 clonidine overdose, pp. 611-615. DOI 10.1345 aph.19257© 2000 Harvey Whitney Books Company. This Article PDF Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Cited by other online articles Articles Ahead of Print Order Reprint Google Scholar Articles by Frye clonidine overdose, C. Articles by Vance clonidine overdose, M. Articles citing this Article PubMed PubMed Citation Articles by Frye clonidine overdose, C. Articles by Vance clonidine overdose, M. Research Articles Hypertensive crisis and myocardial infarction following massive clonidine overdose CB Frye and MA Vance OBJECTIVE: To describe a patient who experienced a hypertensive crisis and myocardial infarction following a massive dose of parenteral clonidine. CASE SUMMARY: A 62-year-old white woman with stage 3 breast cancer metastatic to the spine and a history of hypertension received a combined injection of hydromorphon clonidine overdose.

clonidine overdose E. Excerpt: Symptoms usually resolve in 24 h Deaths are rare Similar symptoms may occur after ingestion of topical nasal decongestants chemically similar to clonidine (oxymetazoline clonidine overdose, tetrahydrozoline clonidine overdose, -naphazoline clonidine overdose, brimonidine) The content above is only an excerpt.For full access subscribe today or log into an existing user account below. AccessMedicine Log In: Username: Password: Log In Forgot your Username Password? Send us the email address that you registered with and we'll send you a reminder. Your email: Submit Still having trouble logging in? Email customer service or call us at 1 (888) 307-5984 or 1 (614) 759-3663. About AccessMedicine AccessMedicine is a subscription-based website that features continually updated medical content from favorite medical titles clonidine overdose, including Harrison's Principles of Internal Medicine. Subscribers also enjoy: 10 major clinical titles covering internal medicine clonidine overdose, emergency medicine clonidine overdose, dermatology clonidine overdose, obstetrics clonidine overdose, cardiology clonidine overdose, pharmacology and more. Over 30 La.

clonidine overdose D the clonidine which was labeled 0.05 mg 5ml with an instruction to take one teaspoon at night. The child received the first dose from this bottle at night and 20 minutes later he was found limp and unresponsive. The father tasted the content of the newly refilled clonidine suspension and within 20 minutes he felt dizzy. He was admitted to the pediatric intensive care unit (PICU) and he was intubated to assist his breathing. He was given atropin and naloxone intravenously and other supportive measures were done at the PICU. After 42 hours of hospitalization he was sent home back to his normal state. A serum level of clonidine was done and it was 64.0 ng ml. This is the highest ever reported level of clonidine in a child. The error in this case was wrong compounding of the clonidine at the pharmacy that resulted to a 1000-fold error in drug compounding. There has been four reports of deaths from clonidine overdose as an acute single drug ingestion. A three year old girl who accidentall.

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clonidine overdose that seems unusual or that is especially bothersome. What other drugs will affect Clonidine? Clonidine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves. Before taking clonidine, tell your doctor if you are taking any of the following medicines: a beta-blocker such as atenolol (Tenormin), acebutolol (Sectral), propranolol (Inderal), metoprolol (Lopressor), carvedilol (Coreg), carteolol (Cartrol), labetalol (Normodyne, Trandate), or nadolol (Corgard); levodopa (Dopar, Larodopa, Sinemet); prazosin (Minipress); or verapamil (Verelan, Calan, Isoptin, Covera-HS); or a tricyclic antidepressant such as amitriptyline (Elavil, Endep), imipramine (Tofranil), nortriptyline (Pamelor, doxepin (Sinequan), and others. You may requi

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