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clonidine hci G the effects of light. However clonidine hci, intraperitoneal injections of norepinephrine clonidine hci, methoxamine and phenylephrine into similar groups of animals had no significant effect on enzyme acitivity. When clonidine and norepinephrine were administered intraventricularly clonidine hci, there was a rapid reduction in enzyme activity. On the other hand clonidine hci, intraventricular administration of phenylephrine did not result in reduced enzyme activity. Pretreatment of animals with phenoxybenzamine failed to block the reduction in NAT activity precipitated by low doses of clonidine. This clonidine-mediated reduction in enzyme activity was clonidine hci, however clonidine hci, blocked by yohimbine. When animals were simultaneously exposed to light and administered clonidine clonidine hci, the rapid reduction in NAT activity was affected only when animals were pretreated with both yohimbine and phenoxybenzamine. In contrast to the decrease in pineal NAT activity observed in in vivo preparations clonidine hci, incubation of pineals with clonidine in an organ culture system produced .
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160; & 160;& 160; Titre du document Document titleEpinephrine increases spinal cord concentrations of 3 H -clonidine hydrochloride in rabbits after epidural infusionAuteur(s) Author(s)FU E. S. (1) ; NAIDU K. A. (2) ; PROCKOP L. D. (2) ; Affiliation(s) du ou des auteurs Author(s) Affiliation(s)(1) Department of Anesthesiology, University of South Florida College of Medicine, Tampa, Florida, ETATS-UNIS(2) Department of Neurology, University of South Florida College of Medicine, Tampa, Florida, ETATS-UNISRésumé AbstractEpinephrine is often given with epidurally administered drugs to prolong and enhance analgesia, which is partly attributed to α-adrenergic processes. This investigation evaluates the effect of epinephrine on the distribution of epidurally administered 3 H -clonidine hydrochloride (clonidine HCI) in serum and in the central nervous system. After placing a lumbar epidural catheter via a laminectomy, rabbits were randomly assigned to receive 20 μCi of clonidine HCI
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