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Netheless, since reports are very limited, caution is warranted in treating nursing mothers with clonidine. SIDE EFFECTS: The most common side effects noted with clonidine are tiredness, lethargy, drowsiness, constipation, and dry mouth. Headache, dizziness, fatigue, and weakness also occur with clonidine. Most persons who experience one of these side effects will usually note that the effects subside with more prolonged therapy or if doses are reduced (approved by the physician). Skin reactions including redness, itching, and darkening of skin, have occurred with clonidine patches. Sexual dysfunction including impotence, decreased sexual desire, and ejaculatory dysfunction, have been reported with clonidine therapy. Such reactions also have been reported with other medications used to treat hypertension. Severe rebound high blood pressure can occur following withdrawal from clonidine. This reaction is more likely to occur if clonidine is stopped suddenly (without a gradual dose reduct
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